A pocket clip is practical, but it is also a visible design element. On a knife designed to allow its removal, taking it off can reveal a cleaner handle and make the object feel more like a traditional pocket knife.
For a cleaner pocket line.

Keep the pocket line clean: no visible clip or exposed handle. Choose a knife that can be carried securely and fully inside the pocket, with a carry arrangement appropriate to its design.
Illustrative comparison, not a specific product.What changes
The handle may feel different without raised hardware against the hand. The pocket opening loses its visible clip. The knife also loses the position that clip maintained: it can turn, lie horizontally, or settle deeper into a pocket. Easier on the eye does not automatically mean easier to retrieve.
Confirm that removal is intended
Visible screws are not enough evidence. Consult the manufacturer’s instructions for the exact version. Clip hardware may interact with other parts of the assembly, and removing or reusing it incorrectly can cause problems. Do not assume that a reversible clip is intended to be used without a clip.
Consider what is left behind
Mounting holes, recesses, and exposed attachment points become part of the finished appearance. Some designs offer appropriate filler pieces or replacement hardware; others do not. Use only the parts and procedure specified for the knife.
A pocket arrangement, not just a modification
Think about retention and separation from keys or other objects. A correctly sized protective slip may be worth considering, provided it suits the knife and allows safe access. Follow the knife’s instructions; do not assume a slip prevents accidental opening or solves an unsuitable carry arrangement.
Choose for the clean pocket line
The aim is a clean pocket opening, not clip removal for its own sake. A knife may keep its clip attached while carried fully inside the pocket, if that arrangement is appropriate for the design. A deep-carry clip still leaves hardware visible. If secure carry depends on hooking a clip over the pocket edge, choose a different knife for this wardrobe rather than compromising retention.